Amino acid sequence data on glial fibrillary acidic protein (GFA); implications for the subdivision of intermediate filaments into epithelial and non-epithelial members.
نویسندگان
چکیده
منابع مشابه
The application of glial fibrillary acidic (GFA) protein immunohistochemistry in neurooncology. A progress report.
Glial fibrillary acidic (GFA) protein, a protein originally isolated from fibrous neuroglia (Eng et aI., 1971) and subsequently localized by specific immunofluorescence to fibrillary astrocytes (Bignami et ai, 1972; Bignami and Dahl, 1974; Uyeda et aI., 1972), is currently being used as an antigenic marker for the investigation of normal, developing and pathologically altered supporting cells o...
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In analogy to experimental results previously obtained with vimentin and neurofilament triplet proteins, the intermediate filament (IF) proteins desmin and glial fibrillary acidic protein (GFAP) were also found to have high capacities to associate with nucleic acids. Employing a collection of native and heat-denatured pro- and eukaryotic DNAs, a series of naturally occurring single-stranded (ss...
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The development of human pineal astrocytes was studied in a prospective autopsy series of 115 cases with an age range of 24 weeks of gestation to 91 years. Pineal glands selected from cases with postmortem intervals of one to 24 hours were fixed in Bouin's fluid and immunostained using the peroxidase-antiperoxidase technique and an antiserum against human glial fibrillary acidic (GFA) protein. ...
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Fifty-five retinoblastoma specimens were studied by a sensitive immunoperoxidase method to determine the intermediate filament types present in human retina and retinoblastoma. Polyclonal antiserum against vimentin and monoclonal antibodies to glial fibrillary acidic protein (GFAP) and to the 200 kD neurofilament triplet protein were used. In the human retina, Müller's cells coexpressed vimenti...
متن کاملStructure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family.
We report the complete sequence of the gene encoding mouse glial fibrillary acidic protein (GFAP), the intermediate filament (IF) protein specific to astrocytes. The 9.8 kb gene includes nine exons separated by introns ranging in size from 0.2 to 2.5 kb. A comparison of the organization of the GFAP gene with that of genes encoding other IF proteins reveals that the structure of IF genes is high...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1983
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1983.tb01700.x